Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even Without Weight Loss in Men With Prediabetes

Cell Metab. 2018 Jun 5;27(6):1212-1221.e3. doi: 10.1016/j.cmet.2018.04.010. Epub 2018 May 10.

Abstract

Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether these effects are due solely to weight loss. We conducted the first supervised controlled feeding trial to test whether IF has benefits independent of weight loss by feeding participants enough food to maintain their weight. Our proof-of-concept study also constitutes the first trial of early time-restricted feeding (eTRF), a form of IF that involves eating early in the day to be in alignment with circadian rhythms in metabolism. Men with prediabetes were randomized to eTRF (6-hr feeding period, with dinner before 3 p.m.) or a control schedule (12-hr feeding period) for 5 weeks and later crossed over to the other schedule. eTRF improved insulin sensitivity, β cell responsiveness, blood pressure, oxidative stress, and appetite. We demonstrate for the first time in humans that eTRF improves some aspects of cardiometabolic health and that IF's effects are not solely due to weight loss.

Keywords: blood pressure; circadian rhythms; circadian system; eTRF; early time-restricted feeding; insulin resistance; insulin sensitivity; intermittent fasting; meal timing; prediabetes.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Blood Pressure*
  • Fasting / metabolism*
  • Humans
  • Insulin Resistance*
  • Insulin-Secreting Cells / metabolism
  • Male
  • Middle Aged
  • Oxidative Stress*
  • Prediabetic State / diet therapy*
  • Prediabetic State / metabolism
  • Proof of Concept Study
  • Weight Loss*