Dynamic thiol/disulphide homeostasis in acute pancreatitis

Turk J Gastroenterol. 2018 May;29(3):348-353. doi: 10.5152/tjg.2018.17499.


Background/aims: The dynamic thiol/disulfide homeostasis plays pivotal roles in many physiological mechanisms in an organism. We aimed to investigate whether dynamic thiol/disulfide homeostasis changes among patients with acute pancreatitis.

Materials and methods: This prospective trial contained 45 patients with acute pancreatitis and 45 sex-and age-matched healthy volunteers as control group. Thiol/disulfide homeostasis parameters were measured by a novel and automated assay, and detected results were compared between the two groups.

Results: Disulfide/total thiol percent ratio and disulfide/native thiol percent ratios were significantly higher in acute pancreatitis group; besides the native thiol, total thiol levels and native thiol/total thiol percent ratios were significantly lower (for all p < 0.001).

Conclusion: The thiol/disulfide homeostasis is impaired in acute pancreatitis with a shift toward the oxidative status, and this deficiency might be a pathogenic factor in acute pancreatitis. The correction of this thiol/disulfide imbalance may be a new target in the management of acute pancreatitis.

Publication types

  • Clinical Trial

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Disulfides / blood*
  • Female
  • Homeostasis / physiology*
  • Humans
  • Male
  • Middle Aged
  • Oxidative Stress / physiology
  • Pancreatitis / blood*
  • Prospective Studies
  • Sulfhydryl Compounds / blood*


  • Disulfides
  • Sulfhydryl Compounds