siRNA: an alternative treatment for diabetes and associated conditions

J Drug Target. 2019 Feb;27(2):174-182. doi: 10.1080/1061186X.2018.1476518. Epub 2018 May 29.


Diabetes is a condition that is not completely treatable but life of a diabetic patient can be smoothed by preventing or delaying the associate conditions like diabetic retinopathy, nephropathy, impaired wound healing process, etc. Apart from conventional methods to regulate diabetic condition, new techniques using siRNA have been emerged to prevent the associated conditions. This paper focuses on how siRNA used as a tool to silence the expression of genes which plays critical role in pathogenesis of these conditions. A marked improvement in wound-healing process of diabetic patients has been observed with siRNA treatment by silencing of Keap1 gene. Glucagon plays critical role in glucose homoeostasis and increases blood glucose level during hypoglycaemia. Glucose homoeostasis is impaired in diabetic patient and suppressing the expression of glucagon secretion with siRNA is used to suppress the progress of diabetes. Similarly, silencing expression of several factors has demonstrated improvement of treatment of diabetic nephropathy, retinopathy and inflammation by the use of siRNA.

Keywords: Diabetes; nephropathy; retinopathy; siRNA.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Complications / prevention & control*
  • Diabetes Mellitus / therapy*
  • Glucose / metabolism
  • Humans
  • RNA Interference*
  • RNA, Small Interfering / therapeutic use*


  • RNA, Small Interfering
  • Glucose