Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families

Matrix Biol. 2019 Jan;75-76:114-125. doi: 10.1016/j.matbio.2018.05.003. Epub 2018 May 17.


The extracellular matrix (ECM) regulates numerous cellular events in addition to providing structural integrity. Among several protein and enzyme families implicated in functions of the ECM, the lysyl oxidases and ADAMTS proteins are known to participate in microfibril and elastic fiber formation as well as ECM-associated signaling. A yeast two-hybrid screen to identify lysyl oxidase (LOX) binding proteins identified ADAMTSL4 as a potential interactor. We demonstrate here that several members of the LOX and ADAMTS families interact with one another. Upon investigating the interaction between LOX and ADAMTSL2 we found that the absence or inhibition of Lox affected ADAMTSL2 molecular forms and reduced its tissue levels. Thus, ADAMTSL2 stability and inter-molecular complexes may depend on the activity of lysyl oxidases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ADAMTS Proteins / genetics*
  • Animals
  • Elastic Tissue / chemistry
  • Elastic Tissue / metabolism
  • Extracellular Matrix / chemistry
  • Extracellular Matrix / genetics*
  • Extracellular Matrix Proteins / chemistry
  • Extracellular Matrix Proteins / genetics
  • Humans
  • Mice
  • Microfibrils / genetics
  • Multiprotein Complexes / chemistry
  • Multiprotein Complexes / genetics*
  • Protein Binding
  • Protein Interaction Maps
  • Protein-Lysine 6-Oxidase / genetics*
  • Signal Transduction


  • ADAMTSL4 protein, human
  • Extracellular Matrix Proteins
  • Multiprotein Complexes
  • LOX protein, human
  • Protein-Lysine 6-Oxidase
  • ADAMTS Proteins
  • ADAMTSL2 protein, human