Granulocyte activating factor released from Propionibacterium acnes. A possible mediator of inflammation in acne vulgaris

Zentralbl Bakteriol Mikrobiol Hyg A. 1988 Nov;270(1-2):246-51. doi: 10.1016/s0176-6724(88)80160-3.


Incubation of Propionibacterium acnes but not of Propionibacterium granulosum or Propionibacterium avidum (for 30 min at 37 degrees C in physiological saline) released a soluble factor that produced enhanced chemiluminescence response of human granulocytes as well as increased chemotactic motility of these cells. Sephadex G-25 filtration of the granulocyte activating factor (GAF) revealed its low molecular weight and apparent peptide character. Thus, GAF may be a stimulus for inflammation in acne vulgaris since low molecular weight chemotactic factors can be expected to penetrate follicular walls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acne Vulgaris / etiology*
  • Acne Vulgaris / pathology
  • Chemotaxis, Leukocyte
  • Chromatography, Gel
  • Granulocytes / immunology*
  • Humans
  • Inflammation
  • Kinetics
  • Luminescent Measurements
  • Molecular Weight
  • Peptides / analysis
  • Peptides / immunology*
  • Peptides / metabolism
  • Propionibacterium acnes / immunology*


  • Peptides