Diagnosis and Treatment of Gout and Pseudogout for Everyday Practice

Prim Care. 2018 Jun;45(2):213-236. doi: 10.1016/j.pop.2018.02.004.


Gout and pseudogout are crystalline arthropathies commonly seen in primary care. It is important to understand their pathophysiology to facilitate recognition and appropriate treatment. Prompt gouty arthritis treatment relieves short-term suffering. Long-term treatment with urate-lowering therapy prevents recurrent attacks and is generally well-tolerated though flare risk is increased during treatment initiation. When anti-inflammatory medications are prescribed, the flare risk is low. Pseudogout acute treatment is similar to acute gouty arthritis treatment. There is no standard regimen for long-term chronic therapies of pseudogout. This article enhances the recognition and treatment of these diseases in the primary care setting.

Keywords: Arthritis; Calcium pyrophosphate deposition disease; Crystalline arthropathy; Gout; Monoarthritis; Polyarthritis; Pseudogout; Urate-lowering therapy.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use*
  • Anti-Inflammatory Agents, Non-Steroidal
  • Arthritis, Gouty / diagnosis*
  • Arthritis, Gouty / drug therapy*
  • Arthritis, Gouty / therapy*
  • Chondrocalcinosis / diagnosis
  • Chondrocalcinosis / therapy
  • Female
  • Gout Suppressants / therapeutic use*
  • Humans
  • Male
  • Primary Health Care / organization & administration*
  • Referral and Consultation


  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Gout Suppressants