The Seronegative Spondyloarthropathies

Ayyappa S Duba; Stephanie D Mathew

doi:10.1016/j.pop.2018.02.005

The Seronegative Spondyloarthropathies

Prim Care. 2018 Jun;45(2):271-287. doi: 10.1016/j.pop.2018.02.005.

Authors

Ayyappa S Duba¹, Stephanie D Mathew²

Affiliations

¹ Department of Rheumatology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA.
² Department of Rheumatology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA. Electronic address: Smathew7@gmail.com.

PMID: 29759124
DOI: 10.1016/j.pop.2018.02.005

Abstract

The seronegative spondyloarthropathies are a group of five diseases characterized by inflammatory oligoarticular arthritis, enthesitis, and axial involvement. They have an increased incidence of the HLA-B27 gene. They are commonly associated with extra-articular features including involvement of the skin, eyes, and gastrointestinal tract. Early recognition and referral are key to limit disability, and comanagement with primary care and rheumatology offers the best outcomes.

Keywords: Ankylosing spondylitis; Enteropathic arthritis; Psoriatic arthritis; Reactive arthritis; Seronegative spondyloarthropathy.

Publication types

Review

MeSH terms

Arthritis, Psoriatic / diagnosis
Arthritis, Psoriatic / immunology
Arthritis, Reactive / diagnosis
Arthritis, Reactive / immunology
HLA-B27 Antigen / analysis*
Humans
Spondylarthropathies / diagnosis*
Spondylarthropathies / immunology*
Spondylitis, Ankylosing / diagnosis
Spondylitis, Ankylosing / immunology

Substances

HLA-B27 Antigen