The Seronegative Spondyloarthropathies

Prim Care. 2018 Jun;45(2):271-287. doi: 10.1016/j.pop.2018.02.005.


The seronegative spondyloarthropathies are a group of five diseases characterized by inflammatory oligoarticular arthritis, enthesitis, and axial involvement. They have an increased incidence of the HLA-B27 gene. They are commonly associated with extra-articular features including involvement of the skin, eyes, and gastrointestinal tract. Early recognition and referral are key to limit disability, and comanagement with primary care and rheumatology offers the best outcomes.

Keywords: Ankylosing spondylitis; Enteropathic arthritis; Psoriatic arthritis; Reactive arthritis; Seronegative spondyloarthropathy.

Publication types

  • Review

MeSH terms

  • Arthritis, Psoriatic / diagnosis
  • Arthritis, Psoriatic / immunology
  • Arthritis, Reactive / diagnosis
  • Arthritis, Reactive / immunology
  • HLA-B27 Antigen / analysis*
  • Humans
  • Spondylarthropathies / diagnosis*
  • Spondylarthropathies / immunology*
  • Spondylitis, Ankylosing / diagnosis
  • Spondylitis, Ankylosing / immunology


  • HLA-B27 Antigen