The influence of THC:CBD oromucosal spray on driving ability in patients with multiple sclerosis-related spasticity

Brain Behav. 2018 Apr 6;8(5):e00962. doi: 10.1002/brb3.962. eCollection 2018 May.


Background: Driving ability is a key function for the majority of patients with multiple sclerosis (MS) to help maintain daily interactions. Both physical and cognitive disability, as well as treatments, may affect the ability to drive. Spasticity is a common symptom associated with MS, and it may affect driving performance either directly or via the medications used to treat it. In this article, we review the evidence relating the antispasticity medicine, Δ9-tetrahydrocannabinol:cannabidiol (THC:CBD) oromucosal spray (Sativex®), and its potential impact on driving performance.

Methods: Articles were identified by searching PubMed from 1/1/2000 to 30/6/2017 using a specified list of search terms. The articles identified using these search terms were augmented with relevant references from these papers and other articles known to the authors.

Results: The results from THC:CBD oromucosal spray driving studies and real-world registries did not show any evidence of an increase in motor vehicle accidents associated with THC:CBD oromucosal spray. The majority of patients reported an improvement in driving ability after starting THC:CBD oromucosal spray, and it was speculated that this may be related to reduced spasticity and/or better cognitive function. It should be noted that THC blood levels are significantly lower than the levels associated with recreational use of herbal cannabis.

Conclusions: THC:CBD oromucosal spray was shown not to impair driving performance. However, periodic assessment of patients with MS driving ability is recommended, especially after relapses and changes in treatment. Blood THC measurements might be above authorized thresholds for some countries following administration of THC:CBD oromucosal spray, thus specific knowledge of each country's driving regulations and a medical certificate are recommended.

Keywords: Sativex; driving ability; multiple sclerosis; oromucosal; spasticity; tetrahydrocannabinol/cannabidiol.

Publication types

  • Review

MeSH terms

  • Automobile Driving*
  • Cannabidiol* / administration & dosage
  • Cannabidiol* / adverse effects
  • Cognition / drug effects
  • Dronabinol* / administration & dosage
  • Dronabinol* / adverse effects
  • Drug Combinations
  • Humans
  • Multiple Sclerosis* / drug therapy
  • Multiple Sclerosis* / physiopathology
  • Multiple Sclerosis* / psychology
  • Muscle Spasticity / drug therapy*
  • Muscle Spasticity / etiology
  • Neuromuscular Agents / administration & dosage
  • Neuromuscular Agents / adverse effects


  • Drug Combinations
  • Neuromuscular Agents
  • Cannabidiol
  • Dronabinol
  • nabiximols