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. 2018 Nov;14(11):1406-1415.
doi: 10.1016/j.jalz.2018.03.011. Epub 2018 May 12.

Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study

David S Knopman  1 , Rebecca F Gottesman  2 , A Richey Sharrett  3 , Amanda L Tapia  4 , Sonia DavisThomas  4 , B Gwen Windham  5 , Laura Coker  6 , Andrea L C Schneider  2 , Alvaro Alonso  7 , Josef Coresh  3 , Marilyn S Albert  2 , Thomas H Mosley Jr  5
Affiliations

Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study

David S Knopman et al. Alzheimers Dement. 2018 Nov.

Abstract

Introduction: The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood.

Methods: In the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45-64 years. In 2011-2013, 20-25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and were given adjudicated diagnoses of cognitively normal, MCI, or DEM.

Results: In 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity, and hypercholesterolemia were associated with late-life MCI and DEM. Low midlife cognition function was also associated with greater likelihood of late-life MCI or DEM. Both midlife vascular risk factors and midlife cognitive function remained associated with later life MCI or DEM when both were in the model.

Discussion: Later life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition.

Keywords: APOE; Cognition; Dementia; Diabetes; Epidemiology; Hypertension; Mild cognitive impairment; Prevalence.

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