Current Practices of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Peritoneal Surface Malignancies: An International Survey of Oncologic Surgeons

World J Surg Oncol. 2018 May 15;16(1):92. doi: 10.1186/s12957-018-1377-7.

Abstract

Background: The goal of the study was to investigate the current clinical practices among oncologic surgeons regarding cytoreductive surgery (CRS) with intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC).

Methods: From September to October 2016, an online questionnaire surveyed the oncologic surgeons by email. The questionnaire included 20 multiple-choice questions of the following: eligibility for the CRS with HIPEC procedure, perioperative staging and surgery skill, assessment of residual tumors, and method used for intraperitoneal HIPEC.

Results: The response rate was 16% (34/217). The majority of respondents (68%) worked at a university hospital. All respondents indicated that mesenteric invasion is the most crucial factor affecting treatment decision. Most surgeons (79%) used the Sugarbaker's staging system to intraoperatively measure the extent of peritoneal invasion. The methods used to measure the extent of miliary pattern of residual tumor spread, and the amount of residual tumor after electrocauterization varied among the surgeons. Most responders (65%) used the closed system of HIPEC.

Conclusions: Despite the fact that CRS HIPEC is the standard treatment for PSM, the clinical practices are very different according to each clinical situation. Nevertheless, mesenteric invasion was found to be the most important factor impacting the treatment decision-making by the majority of responders.

Keywords: Cytoreductive surgery; International survey; Intraoperative hyperthermic intraperitoneal chemotherapy; Peritoneal surface malignancies.

MeSH terms

  • Adult
  • Chemotherapy, Cancer, Regional Perfusion / methods*
  • Cytoreduction Surgical Procedures / methods*
  • Female
  • Humans
  • Hyperthermia, Induced / methods*
  • International Agencies
  • Male
  • Middle Aged
  • Peritoneal Neoplasms / pathology
  • Peritoneal Neoplasms / therapy*
  • Practice Patterns, Physicians'*
  • Prognosis
  • Surgeons / statistics & numerical data
  • Surveys and Questionnaires*
  • Survival Rate