Evaluation of the Ovarian Reserve in Adolescents with Hashimoto’s Thyroiditis Using Serum Anti-Müllerian Hormone Levels

J Clin Res Pediatr Endocrinol. 2018 Nov 29;10(4):331-335. doi: 10.4274/jcrpe.0047. Epub 2018 May 16.


Objective: This study aims to evaluate ovarian reserve in adolescent girls with Hashimoto’s thyroiditis (HT) by assessment of serum anti-Müllerian hormone (AMH) levels. It was hypothesized that HT decreases ovarian reserve and AMH levels are lower in the HT group.

Methods: Thirty HT patients, aged between 10-18 years, and 30 healthy girls as the control group were enrolled in this cross-sectional study. The mean serum AMH levels of the groups were compared using the Mann-Whitney U test.

Results: There was no statistically significant difference between the patient and the control groups in terms of serum AMH levels. There was a negative correlation between serum AMH and thyroid stimulating hormone (TSH) levels and no correlation between serum AMH and anti-thyroid peroxidase (anti-TPO) or anti-thyroglobulin (anti-Tg) antibody levels.

Conclusion: Our results show that ovarian reserve of adolescent girls, as measured by serum AMH levels, is not affected by HT. Autoimmune damage to the ovaries may take time and the adolescent period may be too early to see these effects. Follow up of the patients for reproductive abnormalities and initiation of prospective studies is recommended.

Keywords: ovarian reserve; Hashimoto’s thyroiditis; anti-Müllerian hormone; adolescents.

MeSH terms

  • Adolescent
  • Anti-Mullerian Hormone / blood*
  • Autoantibodies / blood
  • Child
  • Cross-Sectional Studies
  • Female
  • Hashimoto Disease / blood*
  • Hashimoto Disease / physiopathology*
  • Humans
  • Iodide Peroxidase / immunology
  • Ovarian Reserve / physiology*
  • Thyrotropin / blood


  • Autoantibodies
  • anti-thyroglobulin
  • Anti-Mullerian Hormone
  • Thyrotropin
  • Iodide Peroxidase