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Review
. 2017 Nov 9;3(1):99-110.
doi: 10.3233/BPL-170047.

Autophagy and Adult Neurogenesis: Discoveries Made Half a Century Ago Yet in Their Infancy of Being Connected

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Free PMC article
Review

Autophagy and Adult Neurogenesis: Discoveries Made Half a Century Ago Yet in Their Infancy of Being Connected

Jagroop Dhaliwal et al. Brain Plast. .
Free PMC article

Abstract

Within the brain, the physiological and pathological functions of autophagy in development and throughout the lifespan are being elucidated. This review summarizes recent in vitro and in vivo results that are defining the role of autophagy-related genes during the process of adult neurogenesis. We also discuss the need for future experiments to determine the molecular mechanism and functional significance of autophagy in the different neural stem cell populations and throughout the stages of adult neurogenesis.

Figures

Fig.1
Fig.1
The mammalian autophagy pathway. The key steps involved in autophagy and critical members of the autophagy pathway are illustrated. The members of the autophagy pathway that have thicker black circles are those that have been studied in relation to autophagy and adult neurogenesis, as listed in Table 2, and described within the text.

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