Homeostatic responses to amino acid insufficiency

Anim Nutr. 2015 Sep;1(3):135-137. doi: 10.1016/j.aninu.2015.10.001. Epub 2015 Oct 24.


This article provides a brief overview describing how two key signaling pathways, namely the integrated stress response and the mammalian target of rapamycin complex 1, work together to facilitate cellular adaptation to dietary amino acid insufficiency. A deeper understanding of these mechanisms is leading to identification of novel targets which aid in disease treatments, improve stress recovery and increase health span through slowed aging and enhanced metabolic fitness.

Keywords: Activating transcription factor 4; Asparaginase; Eukaryotic initiation factor 2; GCN2; Integrated stress response; mTOR.

Publication types

  • Review