A Worm's Gut Feelings: Neuronal Muscarinic and Epithelial Canonical Wnt Pathways Promote Antimicrobial Defense

Immunity. 2018 May 15;48(5):839-841. doi: 10.1016/j.immuni.2018.04.035.


Molecular mechanisms connecting the gut-brain axis to immunity remain elusive. In this issue of Immunity, Labed et al. (2018) demonstrate that two evolutionarily conserved signaling mechanisms, the neuronal muscarinic and the epithelial Wnt pathways, together induce antimicrobial peptide expression that protects Caenorhabditis elegans against intestinal infection.

Publication types

  • Comment

MeSH terms

  • Acetylcholine
  • Animals
  • Anti-Infective Agents
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins*
  • Cholinergic Agents
  • Emotions
  • Wnt Signaling Pathway*


  • Anti-Infective Agents
  • Caenorhabditis elegans Proteins
  • Cholinergic Agents
  • Acetylcholine