Synergistic Anticancer Effects of Nanocarrier Loaded With Berberine and miR-122

Biosci Rep. 2018 Jun 27;38(3):BSR20180311. doi: 10.1042/BSR20180311. Print 2018 Jun 29.

Abstract

We introduced polyethyleneimine (PEI)-cholesterol (PC) as a nanocarrier incorporating berberine (BER) and miR-122 for the treatment of oral squamous cell carcinoma (OSCC). BER was stabilized by incorporating PC to form ber-PC. Ber-PC was further electrostatically complexed with miR-122 to yield mr-ber-PC for the co-delivery of BER and miR-122. mr-ber-PC treatment dramatically decreased the level of invasion and migration of OSCC cells compared with single drug treatments. The present study suggested that PC could be a multifunctional nanocarrier for the co-delivery of anticancer drug BER and miR-122 to significantly increase the anticancer therapeutic effects.

Keywords: OSCC; berberine; miR-122; nanocarrier PC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Berberine / chemistry
  • Berberine / pharmacology*
  • Cell Line, Tumor
  • Cell Movement / drug effects
  • Cell Proliferation / drug effects
  • Cholesterol / chemistry
  • Diffusion Chambers, Culture
  • Drug Carriers*
  • Drug Compounding / methods
  • Drug Dosage Calculations
  • Epithelial Cells / drug effects*
  • Epithelial Cells / metabolism
  • Epithelial Cells / pathology
  • Humans
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Nanoparticles / chemistry
  • Nanoparticles / metabolism*
  • Nanoparticles / ultrastructure
  • Polyethyleneimine / chemistry

Substances

  • Antineoplastic Agents, Phytogenic
  • Drug Carriers
  • MIRN122 microRNA, human
  • MicroRNAs
  • Berberine
  • Polyethyleneimine
  • Cholesterol