New approaches for brain repair-from rescue to reprogramming

Nature. 2018 May;557(7705):329-334. doi: 10.1038/s41586-018-0087-1. Epub 2018 May 16.


The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New approaches using stem-cell-derived cell products and direct cell reprogramming have opened up the possibility of reconstructing neural circuits and achieving better repair. In this Review we briefly summarize the history of neural repair and then discuss these new therapeutic approaches, especially with respect to chronic neurodegenerative disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / cytology*
  • Brain / pathology
  • Brain / physiology*
  • Cellular Reprogramming / physiology*
  • Fetal Tissue Transplantation
  • Humans
  • Nerve Regeneration / physiology*
  • Neurodegenerative Diseases / pathology*
  • Neurodegenerative Diseases / physiopathology
  • Neurodegenerative Diseases / therapy*
  • Regenerative Medicine / methods*
  • Stem Cell Transplantation