Polymicrobial synergy and dysbiosis: An overview

J Indian Soc Periodontol. 2018 Mar-Apr;22(2):101-106. doi: 10.4103/jisp.jisp_385_17.


The oral fissure is immensely inhabited with a number of polymicrobial colonies similar to the intestinal system. Periodontitis is a dysbiotic disease resulting from deviation in subgingival Gram-positive bacteria to Gram-negative bacteria shift from Gram-positive bacteria. The development of periodontal dysbiosis occurs over a broadened timeframe, which slowly turns the symbiotic association of host and microbe to pathogenic. This review highlights a recent paradigm of periodontitis progression has been postulated which challenges the traditional concept of periodontitis being induced by few particular periopathogens such as belonging to red complex, but by a more comprehensive dysbiotic-synergistic community.

Keywords: Dysbiosis; keystone pathogens; polymicrobial synergy; polymicrobial synergy and dysbiosis model.

Publication types

  • Review