Consumption of pomegranate decreases plasma lipopolysaccharide-binding protein levels, a marker of metabolic endotoxemia, in patients with newly diagnosed colorectal cancer: a randomized controlled clinical trial

Food Funct. 2018 May 23;9(5):2617-2622. doi: 10.1039/c8fo00264a.

Abstract

Gut microbiota dysbiosis alters the intestinal barrier function, increases plasma lipopolysaccharide (LPS) levels, which promotes endotoxemia, and contributes to the onset and development of colorectal cancer (CRC). We report here for the first time the reduction of plasma LPS-binding protein (LBP) levels, a marker of endotoxemia, after pomegranate consumption in newly diagnosed CRC patients.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acute-Phase Proteins
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Carrier Proteins / blood*
  • Colorectal Neoplasms / blood*
  • Colorectal Neoplasms / diagnosis
  • Colorectal Neoplasms / diet therapy*
  • Colorectal Neoplasms / metabolism
  • Endotoxemia / blood*
  • Endotoxemia / diagnosis
  • Environmental Biomarkers
  • Female
  • Fruit / metabolism
  • Humans
  • Lythraceae / metabolism*
  • Male
  • Membrane Glycoproteins / blood*
  • Middle Aged

Substances

  • Acute-Phase Proteins
  • Biomarkers
  • Carrier Proteins
  • Environmental Biomarkers
  • Membrane Glycoproteins
  • lipopolysaccharide-binding protein