Black pepper (Piper nigrum) essential oil demonstrates tissue remodeling and metabolism modulating potential in human cells

Phytother Res. 2018 Sep;32(9):1848-1852. doi: 10.1002/ptr.6110. Epub 2018 May 17.


Very few studies have investigated the biological activities of black pepper essential oil (BPEO) in human cells. Therefore, in the current study, we examined the biological activities of BPEO in cytokine-stimulated human dermal fibroblasts by analyzing the levels of 17 important protein biomarkers pertinent to inflammation and tissue remodeling. BPEO exhibited significant antiproliferative activity in these skin cells and significantly inhibited the production of Collagen I, Collagen III, and plasminogen activator inhibitor 1. In addition, we studied the effect of BPEO on the regulation of genome-wide expression and found that BPEO diversely modulated global gene expression. Further analysis showed that BPEO affected many important genes and signaling pathways closely related to metabolism, inflammation, tissue remodeling, and cancer signaling. This study is the first to provide evidence of the biological activities of BPEO in human dermal fibroblasts. The data suggest that BPEO possesses promising potential to modulate the biological processes of tissue remodeling, wound healing, and metabolism. Although further research is required, BPEO appears to be a good therapeutic candidate for a variety of health conditions including wound care and metabolic diseases. Research into the biological and pharmacological mechanisms of action of BPEO and its major active constituents is recommended.

Keywords: black pepper essential oil; caryophyllene; collagen; metabolism; plasminogen activator inhibitor 1; tissue remodeling.

MeSH terms

  • Biomarkers
  • Caco-2 Cells
  • Cytokines / metabolism
  • Fibroblasts / drug effects*
  • Humans
  • Oils, Volatile / pharmacology*
  • Piper nigrum / chemistry*
  • Plant Extracts / pharmacology*
  • Signal Transduction


  • Biomarkers
  • Cytokines
  • Oils, Volatile
  • Plant Extracts