Abstract
The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor-based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.
Publication types
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Clinical Trial, Phase II
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Alkynes
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Anti-Retroviral Agents / therapeutic use*
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Antimalarials / blood*
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Antimalarials / pharmacokinetics
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Antimalarials / therapeutic use
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Antiretroviral Therapy, Highly Active
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Benzoxazines / pharmacokinetics
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Benzoxazines / therapeutic use
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Chloroquine / analogs & derivatives*
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Chloroquine / blood*
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Chloroquine / pharmacokinetics
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Chloroquine / therapeutic use
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Cyclopropanes
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Drug Interactions
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Female
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HIV Infections / drug therapy*
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Humans
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Malaria / drug therapy*
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Male
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Middle Aged
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Protease Inhibitors / pharmacokinetics
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Protease Inhibitors / therapeutic use
Substances
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Alkynes
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Anti-Retroviral Agents
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Antimalarials
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Benzoxazines
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Cyclopropanes
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Protease Inhibitors
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Chloroquine
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efavirenz
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desethylchloroquine