Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine

Clin Infect Dis. 2018 Oct 30;67(10):1617-1620. doi: 10.1093/cid/ciy405.

Abstract

The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor-based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.

Publication types

  • Clinical Trial, Phase II
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alkynes
  • Anti-Retroviral Agents / therapeutic use*
  • Antimalarials / blood*
  • Antimalarials / pharmacokinetics
  • Antimalarials / therapeutic use
  • Antiretroviral Therapy, Highly Active
  • Benzoxazines / pharmacokinetics
  • Benzoxazines / therapeutic use
  • Chloroquine / analogs & derivatives*
  • Chloroquine / blood*
  • Chloroquine / pharmacokinetics
  • Chloroquine / therapeutic use
  • Cyclopropanes
  • Drug Interactions
  • Female
  • HIV Infections / drug therapy*
  • Humans
  • Malaria / drug therapy*
  • Male
  • Middle Aged
  • Protease Inhibitors / pharmacokinetics
  • Protease Inhibitors / therapeutic use

Substances

  • Alkynes
  • Anti-Retroviral Agents
  • Antimalarials
  • Benzoxazines
  • Cyclopropanes
  • Protease Inhibitors
  • Chloroquine
  • efavirenz
  • desethylchloroquine