Hyaluronic acid, an efficient biomacromolecule for treatment of inflammatory skin and joint diseases: A review of recent developments and critical appraisal of preclinical and clinical investigations

Int J Biol Macromol. 2018 Sep:116:572-584. doi: 10.1016/j.ijbiomac.2018.05.068. Epub 2018 May 29.


Hyaluronic acid (HA) plays multifaceted role in regulating various biological processes and maintaining homeostasis into the body. Numerous researches evidenced the biomedical implications of HA in skin repairmen, cancer prognosis, wound healing, tissue regeneration, anti-inflammatory, immunomodulation. The present review was aimed to summarize and critically appraise the recent developments and efficacy of HA for treatment of inflammatory skin and joint diseases. A thorough analysis of the literature revealed that HA based formulations (i.e., gels, creams, autologous graft, thin sheets, soaked gauze, gauze pad, tincture, injection) have shown remarkable efficacy in treating a wide range of inflammatory skin diseases. The safety, tolerability, and efficacy of HA (as intra-articular injection) have also been well-documented for treatment of various types of joint disease including knee osteoarthritic, joint osteoarthritis, canine osteoarthritis, and meniscal swelling. Intra-articular injection of HA produces remarkable reduction in joint pain, synovial inflammation, and articular swelling. A remarkable improvement in chondrocyte density, territorial matrix appearance, reconstitution of superficial amorphous layer of the cartilage, collagen remodelling, and regeneration of meniscus have also been evident in patients treated with HA. Conclusively, we validate that the application/administration of HA is a promising pharmacotherapeutic regimen for treatment of inflammatory skin and joint diseases.

Keywords: Actinic keratosis; Hyaluronic acid; Intra-articular injection; Osteoarthritis; Skin inflammation; Topical application.

Publication types

  • Review

MeSH terms

  • Animals
  • Dermatitis / drug therapy*
  • Dermatitis / metabolism
  • Dermatitis / pathology
  • Humans
  • Hyaluronic Acid / therapeutic use*
  • Inflammation / drug therapy
  • Inflammation / metabolism
  • Inflammation / pathology
  • Joint Diseases / drug therapy*
  • Joint Diseases / metabolism
  • Joint Diseases / pathology


  • Hyaluronic Acid