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Review
. 2018 May 16;8(2):27.
doi: 10.3390/biom8020027.

Antibiofilm Peptides and Peptidomimetics with Focus on Surface Immobilization

Athina Andrea  1 , Natalia Molchanova  2 , Håvard Jenssen  3
Affiliations
Free PMC article
Review

Antibiofilm Peptides and Peptidomimetics with Focus on Surface Immobilization

Athina Andrea et al. Biomolecules. .
Free PMC article

Abstract

Bacterial biofilms pose a major threat to public health, as they are associated with at least two thirds of all infections. They are highly resilient and render conventional antibiotics inefficient. As a part of the innate immune system, antimicrobial peptides have drawn attention within the last decades, as some of them are able to eradicate biofilms at sub-minimum inhibitory concentration (MIC) levels. However, peptides possess a number of disadvantages, such as susceptibility to proteolytic degradation, pH and/or salinity-dependent activity and loss of activity due to binding to serum proteins. Hence, proteolytically stable peptidomimetics were designed to overcome these drawbacks. This paper summarizes the current peptide and peptidomimetic strategies for combating bacteria-associated biofilm infections, both in respect to soluble and surface-functionalized solutions.

Keywords: antibiofilm; peptidomimetics; surface-immobilized peptides.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Medical implant failure risk factors.
Figure 2
Figure 2
Requirements for antimicrobial coatings on medical implants.
Figure 3
Figure 3
Covalent immobilisation of AMPs on titanium surfaces.
Figure 4
Figure 4
AMP release coating strategies on titanium surfaces. CaP: calcium phosphate coating; NT: TiO2 nanotures.
See this image and copyright information in PMC

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