Antibiofilm Peptides and Peptidomimetics with Focus on Surface Immobilization

Biomolecules. 2018 May 16;8(2):27. doi: 10.3390/biom8020027.

Abstract

Bacterial biofilms pose a major threat to public health, as they are associated with at least two thirds of all infections. They are highly resilient and render conventional antibiotics inefficient. As a part of the innate immune system, antimicrobial peptides have drawn attention within the last decades, as some of them are able to eradicate biofilms at sub-minimum inhibitory concentration (MIC) levels. However, peptides possess a number of disadvantages, such as susceptibility to proteolytic degradation, pH and/or salinity-dependent activity and loss of activity due to binding to serum proteins. Hence, proteolytically stable peptidomimetics were designed to overcome these drawbacks. This paper summarizes the current peptide and peptidomimetic strategies for combating bacteria-associated biofilm infections, both in respect to soluble and surface-functionalized solutions.

Keywords: antibiofilm; peptidomimetics; surface-immobilized peptides.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Biocompatible Materials / chemistry*
  • Biocompatible Materials / pharmacology
  • Biofilms / drug effects*
  • Humans
  • Immobilized Proteins / chemistry*
  • Immobilized Proteins / pharmacology
  • Peptidomimetics / chemistry*
  • Peptidomimetics / pharmacology
  • Protein Stability

Substances

  • Anti-Bacterial Agents
  • Biocompatible Materials
  • Immobilized Proteins
  • Peptidomimetics