t(11;14)-positive mantle cell lymphomas lacking cyclin D1 (CCND1) immunostaining because of a CCND1 mutation or exclusive expression of the CCND1b isoform

Haematologica. 2018 Sep;103(9):e432-e435. doi: 10.3324/haematol.2018.192435. Epub 2018 May 17.

Authors

Ingram Iaccarino^{1

2}, Lamis Afify³, Sietse M Aukema³, Katharina Reddemann³, Philipp Schütt⁴, Martin Flür⁵, Wolfram Klapper³

Affiliations

¹ Department of Pathology, Hematopathology Section and Lymph Node Registry, University of Kiel, Kiel, Germany iiaccarino@medgen.uni-kiel.de.
² Institute of Genetics and Biophysics, "A. Buzzati-Traverso", Consiglio Nazionale delle Ricerche, Naples, Italy.
³ Department of Pathology, Hematopathology Section and Lymph Node Registry, University of Kiel, Kiel, Germany.
⁴ Onkologische Schwerpunktpraxis Gütersloh, Germany.
⁵ Helios Klinikum Schwelm, Germany.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 14
Cyclin D1 / genetics*
Cyclin D1 / metabolism*
DNA Mutational Analysis
Female
Gene Expression Regulation, Neoplastic*
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lymphoma, Mantle-Cell / diagnosis
Lymphoma, Mantle-Cell / drug therapy
Lymphoma, Mantle-Cell / genetics*
Lymphoma, Mantle-Cell / metabolism*
Mutation*
Protein Isoforms
Translocation, Genetic*
Treatment Outcome

Substances

CCND1 protein, human
Protein Isoforms
Cyclin D1