BST2 Promotes Cell Proliferation, Migration and Induces NF-κB Activation in Gastric Cancer

Biotechnol Lett. 2018 Jul;40(7):1015-1027. doi: 10.1007/s10529-018-2562-z. Epub 2018 May 17.

Abstract

Objectives: To investigate the functional roles of bone marrow stromal cell antigen 2 (BST2) in gastric cancer (GC) cells and its implications in the development of GC patients.

Results: BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demonstrated that knockdown of BST2 by siRNA inhibited cell proliferation, induced apoptosis and repressed cell motility in GC cells. In addition, the pro-tumor function of BST2 in GC was mediated partly through the NF-κB signaling.

Conclusion: BST2 possesses the oncogenic potential in GC by regulating the proliferation, apoptosis, and migratory ability of GC cells, thereby BST2 could be a potential therapeutic target for the treatment of GC.

Keywords: Apoptosis; BST2; Gastric cancer; NFκB; Proliferation.

MeSH terms

  • Antigens, CD / analysis*
  • Antigens, CD / metabolism
  • Apoptosis / genetics
  • Cell Cycle Checkpoints
  • Cell Line, Tumor
  • Cell Movement / physiology*
  • Cell Proliferation / physiology*
  • GPI-Linked Proteins / analysis
  • GPI-Linked Proteins / metabolism
  • Gastric Mucosa / metabolism
  • Histocytochemistry
  • Humans
  • NF-kappa B / metabolism*
  • Stomach / chemistry
  • Stomach / pathology
  • Stomach Neoplasms / chemistry
  • Stomach Neoplasms / metabolism*
  • Stomach Neoplasms / pathology

Substances

  • Antigens, CD
  • BST2 protein, human
  • GPI-Linked Proteins
  • NF-kappa B