SearchGUI: A Highly Adaptable Common Interface for Proteomics Search and de Novo Engines

J Proteome Res. 2018 Jul 6;17(7):2552-2555. doi: 10.1021/acs.jproteome.8b00175. Epub 2018 May 25.


Mass-spectrometry-based proteomics has become the standard approach for identifying and quantifying proteins. A vital step consists of analyzing experimentally generated mass spectra to identify the underlying peptide sequences for later mapping to the originating proteins. We here present the latest developments in SearchGUI, a common open-source interface for the most frequently used freely available proteomics search and de novo engines that has evolved into a central component in numerous bioinformatics workflows.

Keywords: bioinformatics; de novo algorithms; protein identification; search engines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Computational Biology
  • Proteins / analysis
  • Proteomics / methods*
  • Search Engine / methods*
  • Tandem Mass Spectrometry*
  • Workflow


  • Proteins