At Long Last, a C-Terminal Bookend for the Ubiquitin Code

Andrew Chatr-Aryamontri; Almer van der Sloot; Mike Tyers

doi:10.1016/j.molcel.2018.05.006

At Long Last, a C-Terminal Bookend for the Ubiquitin Code

Mol Cell. 2018 May 17;70(4):568-571. doi: 10.1016/j.molcel.2018.05.006.

Authors

Andrew Chatr-Aryamontri¹, Almer van der Sloot¹, Mike Tyers²

Affiliations

¹ Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC H3C 3J7, Canada.
² Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC H3C 3J7, Canada. Electronic address: md.tyers@umontreal.ca.

PMID: 29775575
DOI: 10.1016/j.molcel.2018.05.006

Abstract

The ubiquitin-proteasome system controls the stability of myriad protein substrates via short sequence motifs called degrons. Studies by Koren et al. (2018) and Lin et al. (2018) have uncovered a broad new class of degrons located at the extreme C terminus of substrates.

Publication types

Comment

MeSH terms

Proteasome Endopeptidase Complex*
Proteins
Ubiquitin*
Ubiquitin-Protein Ligases

Substances

Proteins
Ubiquitin
Ubiquitin-Protein Ligases
Proteasome Endopeptidase Complex