Neurons Are the Inflammatory Problem

Cell. 2018 May 17;173(5):1066-1068. doi: 10.1016/j.cell.2018.05.005.


The discovery that reflex neuronal circuits control immunity provided a new mechanistic understanding of infection and injury. Pinho-Ribeiro et al. (2018) report that lethal tissue destruction from streptococcal necrotizing fasciitis ("flesh-eating disease") occurs because sensory neurons reflexively inhibit frontline immune responses.

Publication types

  • Comment

MeSH terms

  • Fasciitis, Necrotizing*
  • Humans
  • Neurons
  • Streptococcal Infections*