Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2018 Oct;52:14-22.
doi: 10.1016/j.tiv.2018.01.002. Epub 2018 Jun 5.

Formulants of Glyphosate-Based Herbicides Have More Deleterious Impact Than Glyphosate on TM4 Sertoli Cells

Affiliations
Comparative Study

Formulants of Glyphosate-Based Herbicides Have More Deleterious Impact Than Glyphosate on TM4 Sertoli Cells

Alison Vanlaeys et al. Toxicol In Vitro. .

Abstract

Roundup and Glyphogan are glyphosate-based herbicides containing the same concentration of glyphosate and confidential formulants. Formulants are declared as inert diluents but some are more toxic than glyphosate, such as the family of polyethoxylated alkylamines (POEA). We tested glyphosate alone, glyphosate-based herbicide formulations and POEA on the immature mouse Sertoli cell line (TM4), at concentrations ranging from environmental to agricultural-use levels. Our results show that formulations of glyphosate-based herbicides induce TM4 mitochondrial dysfunction (like glyphosate, but to a lesser extent), disruption of cell detoxification systems, lipid droplet accumulation and mortality at sub-agricultural doses. Formulants, especially those present in Glyphogan, are more deleterious than glyphosate and thus should be considered as active principles of these pesticides. Lipid droplet accumulation after acute exposure to POEA suggests the rapid penetration and accumulation of formulants, leading to mortality after 24 h. As Sertoli cells are essential for testicular development and normal onset of spermatogenesis, disturbance of their function by glyphosate-based herbicides could contribute to disruption of reproductive function demonstrated in mammals exposed to these pesticides at a prepubertal stage of development.

Keywords: Cytotoxicity; Formulants; Glyphosate; Lipid droplets; TM4 Sertoli cell line.

Similar articles

See all similar articles

Cited by 2 articles

Publication types

LinkOut - more resources

Feedback