Beating the odds: programming proliferation in the mammalian heart

Genome Med. 2018 May 18;10(1):36. doi: 10.1186/s13073-018-0550-5.


The heart is one of the least regenerative organs in the human body; adult cardiac myocytes divide at extremely low frequency. Therefore, meaningful induction of cardiac regeneration requires in-depth understanding of myocyte cell-cycle control. Recent insights into how myocytes can be coaxed into duplicating in vivo might inform emerging therapeutics.

Keywords: Cyclin; Myocyte; Proliferation; Regeneration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Proliferation
  • Humans
  • Mammals / metabolism*
  • Myocardium / cytology*
  • Regeneration