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. 2018 Sep;72(4):890-896.
doi: 10.1007/s11418-018-1221-y. Epub 2018 May 17.

Comparison of Lawsone Contents Among Lawsonia Inermis Plant Parts and Neurite Outgrowth Accelerators From Branches

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Comparison of Lawsone Contents Among Lawsonia Inermis Plant Parts and Neurite Outgrowth Accelerators From Branches

Yoshimi Oda et al. J Nat Med. .

Abstract

Lawsonia inermis L. (Lythraceae) is cultivated in many countries, including Japan, China, India and Egypt. Its leaves are well known as hair dye and exhibit antibacterial, anticancer, antifungal and anticonvulsant activities. However, there are few reports on its branches. 2-Hydroxy-1,4-naphthoquinone (lawsone) is a characteristic compound in its leaves. However, it remains to be clarified whether lawsone is present in other plant parts or not. In this study, we measured lawsone contents in the extracts of L. inermis flowers, leaves and branches by HPLC with tandem mass spectrometry. The extracts of L. inermis flowers, leaves and branches contained 116.9, 486.2 and 5.4 μg/g lawsone, respectively. Lawsone content was much lower in branches than the other plant parts. Next, in order to identify the biological constituents in the branches, we isolated nine known compounds and examined their effects on neurite outgrowth in PC12 cells. Among the constituents isolated, 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propane-1,3-diol (1) and quercetin 7-O-β-D-glucopyranoside (8) showed accelerative effects on neurite outgrowth in PC12 cells.

Keywords: Branch; Lawsone; Lawsonia inermis; Neurite outgrowth; PC12.

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References

    1. Bioorg Med Chem Lett. 2015 Jul 1;25(13):2702-6 - PubMed
    1. J Agric Food Chem. 2010 Nov 24;58(22):11673-9 - PubMed
    1. Cytotechnology. 2010 Oct;62(5):461-72 - PubMed
    1. Phytochemistry. 2013 Apr;88:67-73 - PubMed
    1. J Pharmacol Sci. 2007 Aug;104(4):349-54 - PubMed

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