Comparison of the etiological relevance of Staphylococcus haemolyticus and Staphylococcus hominis

Eur J Clin Microbiol Infect Dis. 2018 Aug;37(8):1539-1545. doi: 10.1007/s10096-018-3282-y. Epub 2018 May 19.


The study was performed to assess potential differences in the etiological relevance of two coagulase-negative staphylococci (CoNS), Staphylococcus haemolyticus and Staphylococcus hominis, in an observational single-center study. Over a 5-year interval, patients in whom there was detected S. haemolyticus or S. hominis of presumed etiological relevance were assessed for the primary endpoint death during hospital stay and the secondary endpoint transfer to an intensive care unit (ICU) after the detection of S. haemolyticus or S. hominis. Patients with S. haemolyticus or S. hominis died in 11.3% (50 out of 444) and 9.5% (60 out of 631) of cases, respectively, and were transferred to ICU after S. haemolyticus and S. hominis detection in 8.7% (19 out of 219) and 11.7% (44 out of 377) of cases, respectively. There was no significance for species-related influence on the primary outcome parameter (P > 0.1), while ICU transfers were more likely for patients with S. hominis detections (P = 0.016). Delayed diagnosis of both CoNS species was associated with an increased probability of death (P = 0.009). The study revealed comparable morbidity caused by S. haemolyticus and S. hominis identified in a clinically relevant context.

Keywords: Coagulase-negative staphylococci; Etiological relevance; Infection; Staphylococcus haemolyticus; Staphylococcus hominis.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Typing Techniques
  • Biodiversity
  • Coagulase / genetics
  • Germany / epidemiology
  • Humans
  • Incidence
  • Intensive Care Units
  • Length of Stay
  • Outcome Assessment, Health Care
  • Retrospective Studies
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Staphylococcal Infections / diagnosis
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / epidemiology*
  • Staphylococcal Infections / microbiology*
  • Staphylococcus haemolyticus* / classification
  • Staphylococcus haemolyticus* / drug effects
  • Staphylococcus haemolyticus* / genetics
  • Staphylococcus haemolyticus* / isolation & purification
  • Staphylococcus hominis* / classification
  • Staphylococcus hominis* / drug effects
  • Staphylococcus hominis* / genetics
  • Staphylococcus hominis* / isolation & purification


  • Anti-Bacterial Agents
  • Coagulase