RETRACTED: EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway

Qiang Ma; Yijian Zhang; Haibin Liang; Fei Zhang; Fatao Liu; Shili Chen; Yunping Hu; Lin Jiang; Yajuan Hao; Maolan Li; Yingbin Liu

doi:10.1016/j.canlet.2018.05.022

RETRACTED: EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway

Cancer Lett. 2018 Aug 28:430:97-108. doi: 10.1016/j.canlet.2018.05.022. Epub 2018 May 17.

Authors

Qiang Ma¹, Yijian Zhang², Haibin Liang³, Fei Zhang⁴, Fatao Liu⁵, Shili Chen⁶, Yunping Hu⁷, Lin Jiang⁸, Yajuan Hao⁹, Maolan Li¹⁰, Yingbin Liu¹¹

Affiliations

¹ Department of General Surgery, Xinhua Hospital Affiliated with Shanghai Jiao Tong University, School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China; Shanghai Key Laboratory of Biliary Tract Disease Research, No. 1665 Kongjiang Road, Shanghai, 200092, China. Electronic address: mq_729@163.com.
² Department of General Surgery, Xinhua Hospital Affiliated with Shanghai Jiao Tong University, School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China; Shanghai Key Laboratory of Biliary Tract Disease Research, No. 1665 Kongjiang Road, Shanghai, 200092, China. Electronic address: sunshinezyj@126.com.
³ Department of General Surgery, Xinhua Hospital Affiliated with Shanghai Jiao Tong University, School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China; Shanghai Key Laboratory of Biliary Tract Disease Research, No. 1665 Kongjiang Road, Shanghai, 200092, China. Electronic address: 13921604243@163.com.
⁴ Department of General Surgery, Xinhua Hospital Affiliated with Shanghai Jiao Tong University, School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China; Shanghai Key Laboratory of Biliary Tract Disease Research, No. 1665 Kongjiang Road, Shanghai, 200092, China. Electronic address: zhangfei36363636@163.com.
⁵ Department of General Surgery, Xinhua Hospital Affiliated with Shanghai Jiao Tong University, School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China; Shanghai Key Laboratory of Biliary Tract Disease Research, No. 1665 Kongjiang Road, Shanghai, 200092, China. Electronic address: fasterliu@163.com.
⁶ Department of General Surgery, Xinhua Hospital Affiliated with Shanghai Jiao Tong University, School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China; Shanghai Key Laboratory of Biliary Tract Disease Research, No. 1665 Kongjiang Road, Shanghai, 200092, China. Electronic address: chenshilichem@163.com.
⁷ Department of General Surgery, Xinhua Hospital Affiliated with Shanghai Jiao Tong University, School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China; Shanghai Key Laboratory of Biliary Tract Disease Research, No. 1665 Kongjiang Road, Shanghai, 200092, China. Electronic address: kevintony@126.com.
⁸ Department of General Surgery, Xinhua Hospital Affiliated with Shanghai Jiao Tong University, School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China; Shanghai Key Laboratory of Biliary Tract Disease Research, No. 1665 Kongjiang Road, Shanghai, 200092, China. Electronic address: jldaissy@126.com.
⁹ Department of General Surgery, Xinhua Hospital Affiliated with Shanghai Jiao Tong University, School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China; Shanghai Key Laboratory of Biliary Tract Disease Research, No. 1665 Kongjiang Road, Shanghai, 200092, China. Electronic address: haoyajuan@xinhuamed.com.cn.
¹⁰ Department of General Surgery, Xinhua Hospital Affiliated with Shanghai Jiao Tong University, School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China; Shanghai Key Laboratory of Biliary Tract Disease Research, No. 1665 Kongjiang Road, Shanghai, 200092, China. Electronic address: limaolan6@163.com.
¹¹ Department of General Surgery, Xinhua Hospital Affiliated with Shanghai Jiao Tong University, School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China; Shanghai Key Laboratory of Biliary Tract Disease Research, No. 1665 Kongjiang Road, Shanghai, 200092, China. Electronic address: liuyingbin@xinhuamed.com.cn.

PMID: 29778567
DOI: 10.1016/j.canlet.2018.05.022

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor. Following the publication of the above article, the Editor was notified that images were duplicated in the migration and invasion experiments in Figures 3A, 6C, 7D and 8D: https://pubpeer.com/publications/76E82FD26E33503D7CCAC01C324AFA. The Editor has taken the decision to retract the paper as it is no longer acceptable in its current form

Keywords: EMP3; Gallbladder cancer; MAPK/ERK; miR-663a.

Publication types

Research Support, Non-U.S. Gov't
Retracted Publication

MeSH terms

Animals
Cell Line, Tumor
Cell Proliferation / genetics
Cholecystectomy
Disease Progression
Down-Regulation / genetics
Female
Gallbladder / pathology
Gallbladder / surgery
Gallbladder Neoplasms / genetics
Gallbladder Neoplasms / mortality
Gallbladder Neoplasms / pathology*
Gallbladder Neoplasms / surgery
Gene Expression Regulation, Neoplastic
Humans
Kaplan-Meier Estimate
MAP Kinase Signaling System / genetics*
Male
Membrane Glycoproteins / genetics*
Membrane Glycoproteins / metabolism
Mice
Mice, Nude
MicroRNAs / metabolism*
Middle Aged
Neoplasm Staging
Xenograft Model Antitumor Assays

Substances

EMP3 protein, human
MIRN663 microRNA, human
Membrane Glycoproteins
MicroRNAs