[Correlations between insulin sensitivity with anthropometric and metabolic parameters in type 2 diabetics]

Ann Cardiol Angeiol (Paris). 2018 Jun;67(3):167-173. doi: 10.1016/j.ancard.2018.04.021. Epub 2018 May 17.
[Article in French]

Abstract

Aim: The aim of the study was to evaluate correlations between insulin sensitivity and insulinosecretion with anthropometric and metabolic parameters in type 2 diabetics.

Materials and methods: We conducted a cross-sectional study among patients with type 2 diabetes mellitus treated with oral antidiabetic medications. The evaluation of insulin resistance and insulinosecretion was based on the calculation of the HOMA-IR and HOMA-β indices.

Results: The mean age for the 100diabetes recruited was 56.4±8.4years. The mean body mass index (BMI) and waist circumference (WC) were 30.5±5.7kg/m2 and 101.2±11.9cm respectively. The HOMA-IR and HOMA β indices were respectively 3.5±2.8 and 48.9±45.5. We have found a significantly positive correlation between HOMA-IR index and weight (r=0.406, p<10-3), BMI (r=0.432, p<10-3) and WC (r=0.412, p<10-3). We noticed a significant negative correlation between HOMA β index and fasting glucose (r=-0.457, p<10-3) and A1C (r=-0.399, p<10-3). A positive statistically significant correlation was noted between HOMA-IR and HOMA-β (r=0.400, p<10-3).

Conclusion: Insulin resistance is very related to overweight, especially the android distribution of fat hence the need for adequate management of this android obesity. It would also be interesting to evaluate the effects of weight loss on insulin resistance parameters.

Keywords: Body Mass Index; Diabète type 2; HbA1c; Hba1c; Indice de masse corporelle; Insulin resistance; Insulinorésistance; Insulinosécrétion; Type 2 diabetes mellitus.

MeSH terms

  • Adult
  • Aged
  • Body Mass Index*
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / metabolism*
  • Female
  • Humans
  • Insulin Resistance*
  • Male
  • Middle Aged
  • Waist Circumference*