[Effect of Misregistration between SPECT and CT Images on Attenuation Correction for Quantitative Bone SPECT Imaging]

Nihon Hoshasen Gijutsu Gakkai Zasshi. 2018;74(5):452-458. doi: 10.6009/jjrt.2018_JSRT_74.5.452.
[Article in Japanese]


Purpose: The aim of this study was to evaluate the effect of misregistration between single-photon emission computed tomography (SPECT) and computed tomography (CT) images on bone SPECT.

Methods: We acquired SPECT and CT images of a body phantom filled with bone-equivalent solution and 99mTc for evaluation of bone SPECT. SPECT images were reconstructed using attenuation correction maps obtained by shifting the attenuation coefficients from non-shifted values (reference). Activity concentrations, SPECT standardized uptake values (SPECT-SUVs), and tumor background ratios (TBRs) were evaluated.

Results: Activity concentrations and SPECT-SUVs decreased with decreasing attenuation coefficient. The difference in attenuation coefficient was especially large between the shifted-to-lung (0.085 cm-1) and reference (0.249 cm-1) values. Non-shifted and shifted-to-lung SPECT-SUVs were 11.5±1.0 and 2.3±0.2, respectively. TBR also decreased with decreasing attenuation coefficient. The maximum percentage change in TBR was 86% in the shifted-to-lung value.

Conclusions: Our results indicate that the accuracy of activity concentration and lesion detectability was commonly affected by misalignment between SPECT and CT images. Although the impact of SPECT/CT misregistration on bone SPECT is case-specific and difficult to predict, it is important to reduce the incidence of misregistration errors for quantitative bone SPECT imaging.

Keywords: CT attenuation correction; bone scintigraphy; misregistration; quantitative SPECT; single photon emission computed tomography (SPECT).

MeSH terms

  • Bone and Bones
  • Phantoms, Imaging
  • Tomography, Emission-Computed, Single-Photon*
  • Tomography, X-Ray Computed*