Three new cyathane diterpenes with neurotrophic activity from the liquid cultures of Hericium erinaceus

J Antibiot (Tokyo). 2018 Sep;71(9):818-821. doi: 10.1038/s41429-018-0065-8. Epub 2018 May 21.

Abstract

Three new cyathane diterpenes erinacines T-V (1-3), and two known cyathane diterpenes erinacine A (4) and erinacine P (5) were isolated from the liquid cultures of Hericium erinaceus. The structures of 1-3 were determined by extensive spectroscopic analysis. All isolated compounds were evaluated for the cytotoxicity, and neurite-promoting activities using PC12 cell line. Compounds 1-3, and 5 exhibited pronounced neurite outgrowth-promoting effects on PC12 cells in the range of 2.5-10 μM. Compound 4 showed weak cytotoxicity against PC12 cells with IC50 of 73.7 μM.

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Basidiomycota / metabolism
  • Cell Line, Tumor
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Nerve Growth Factors / pharmacology*
  • Neurodegenerative Diseases / drug therapy
  • PC12 Cells
  • Pheochromocytoma / drug therapy*
  • Rats

Substances

  • Antineoplastic Agents
  • Diterpenes
  • Nerve Growth Factors
  • cyathane