Basal cell carcinoma: Contemporary approaches to diagnosis, treatment, and prevention

J Am Acad Dermatol. 2019 Feb;80(2):321-339. doi: 10.1016/j.jaad.2018.02.083. Epub 2018 May 19.


As the most common human cancer worldwide and continuing to increase in incidence, basal cell carcinoma is associated with significant morbidity and cost. Continued advances in research have refined both our insight and approach to this seemingly ubiquitous disease. This 2-part continuing medical education series provides a comprehensive and contemporary review of basal cell carcinoma. The second article in this series will present both the current standard of care and newly developed approaches to diagnosis, treatment, and prevention of this disease.

Keywords: 5-fluorouracil; BCC; Mohs micrographic surgery; basal cell carcinoma; biopsy; confocal microscopy; hedgehog inhibitors; imiquimod; keratinocyte carcinoma; laser; multiphoton tomography; nonmelanoma skin cancer; optical coherence tomography; photodynamic therapy; prevention; radiation.

Publication types

  • Review

MeSH terms

  • Aged
  • Anilides / therapeutic use
  • Biopsy, Needle
  • Carcinoma, Basal Cell / diagnosis*
  • Carcinoma, Basal Cell / prevention & control
  • Carcinoma, Basal Cell / therapy*
  • Dermoscopy / methods
  • Early Detection of Cancer
  • Education, Medical, Continuing
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Mohs Surgery / methods*
  • Photochemotherapy / methods
  • Prognosis
  • Pyridines / therapeutic use
  • Randomized Controlled Trials as Topic
  • Risk Assessment
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / prevention & control
  • Skin Neoplasms / therapy*
  • Tomography, Optical Coherence / methods
  • Tomography, X-Ray Computed / methods
  • Treatment Outcome


  • Anilides
  • HhAntag691
  • Pyridines