Raising NAD in Heart Failure: Time to Translate?

doi:10.1161/CIRCULATIONAHA.117.032626

Editorial

. 2018 May 22;137(21):2274-2277.

doi: 10.1161/CIRCULATIONAHA.117.032626.

Raising NAD in Heart Failure: Time to Translate?

Matthew A Walker¹, Rong Tian²

Affiliations

¹ Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle.
² Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle. rongtian@u.washington.edu.

PMID: 29784680
PMCID: PMC5967641
DOI: 10.1161/CIRCULATIONAHA.117.032626

Editorial

Raising NAD in Heart Failure: Time to Translate?

Matthew A Walker et al. Circulation. 2018.

. 2018 May 22;137(21):2274-2277.

doi: 10.1161/CIRCULATIONAHA.117.032626.

Authors

Matthew A Walker¹, Rong Tian²

Affiliations

¹ Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle.
² Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle. rongtian@u.washington.edu.

PMID: 29784680
PMCID: PMC5967641
DOI: 10.1161/CIRCULATIONAHA.117.032626

No abstract available

Keywords: Editorials; NAD; heart failure; nicotinamide riboside.

PubMed Disclaimer

Figures

**Figure 1**
NAD⁺ biosynthesis, consumption and salvage pathways. The intracellular NAD⁺ pool consists of both oxidized (NAD⁺) and reduced (NADH) forms. Electrons derived from substrate catabolism are carried by NADH and used for oxidative phosphorylation and biosynthetic reactions. NAD⁺ also functions as a co-substrate for sirtuins, ADP-ribose transferases, and cyclic ADP-ribose synthases (CD38). Eukaryotes synthesize NAD⁺ from the amino acid tryptophan via the *de novo* pathway or NAD⁺ can be salvaged from nicotinamide (NAM) and converted into nicotinamide mononucleotide (NMN) by nicotinamide phosphoribosyltransferase (Nampt). NMN can also be generated by the phosphorylation of NR by nicotinamide riboside kinase (Nrk).

See this image and copyright information in PMC

Comment on

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.
Diguet N, Trammell SAJ, Tannous C, Deloux R, Piquereau J, Mougenot N, Gouge A, Gressette M, Manoury B, Blanc J, Breton M, Decaux JF, Lavery GG, Baczkó I, Zoll J, Garnier A, Li Z, Brenner C, Mericskay M. Diguet N, et al. Circulation. 2018 May 22;137(21):2256-2273. doi: 10.1161/CIRCULATIONAHA.116.026099. Epub 2017 Dec 7. Circulation. 2018. PMID: 29217642 Free PMC article.

Cited by

Effects of ranolazine on right ventricular function, fluid dynamics, and metabolism in patients with precapillary pulmonary hypertension: insights from a longitudinal, randomized, double-blinded, placebo controlled, multicenter study.
Han QJ, Forfia P, Vaidya A, Ramani G, deKemp RA, Mach RH, Mankoff DA, Bravo PE, DiCarli M, Chan SY, Waxman AB, Han Y. Han QJ, et al. Front Cardiovasc Med. 2023 Jun 13;10:1118796. doi: 10.3389/fcvm.2023.1118796. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 37383703 Free PMC article.
SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics.
Du Z, Zhou Y, Li Q, Xie Y, Zhu T, Qiao J, Zhang R, Bao Y, Wang L, Xie Y, Quan J, Lin M, Zhang N, Jin Q, Liang W, Wu L, Yin T, Xie Y. Du Z, et al. JACC Basic Transl Sci. 2024 Jul 31;9(10):1211-1230. doi: 10.1016/j.jacbts.2024.05.011. eCollection 2024 Oct. JACC Basic Transl Sci. 2024. PMID: 39534638 Free PMC article.
K_ATP channel dependent heart multiome atlas.
Arrell DK, Park S, Yamada S, Alekseev AE, Garmany A, Jeon R, Vuckovic I, Lindor JZ, Terzic A. Arrell DK, et al. Sci Rep. 2022 May 5;12(1):7314. doi: 10.1038/s41598-022-11323-4. Sci Rep. 2022. PMID: 35513538 Free PMC article.
Mitochondrial complex I deficiency and cardiovascular diseases: current evidence and future directions.
Forte M, Palmerio S, Bianchi F, Volpe M, Rubattu S. Forte M, et al. J Mol Med (Berl). 2019 May;97(5):579-591. doi: 10.1007/s00109-019-01771-3. Epub 2019 Mar 12. J Mol Med (Berl). 2019. PMID: 30863992 Review.
Nicotinamide Riboside Improves Cardiac Function and Prolongs Survival After Disruption of the Cardiomyocyte Clock.
Dierickx P, Carpenter BJ, Celwyn I, Kelly DP, Baur JA, Lazar MA. Dierickx P, et al. Front Mol Med. 2022;2:887733. doi: 10.3389/fmmed.2022.887733. Epub 2022 May 9. Front Mol Med. 2022. PMID: 37389009 Free PMC article.

See all "Cited by" articles

References

1. Ussher JR, Jaswal JS, Lopaschuk GD. Pyridine nucleotide regulation of cardiac intermediary metabolism. Circ Res. 2012;111:628–641. - PubMed
1. Canto C, Menzies KJ, Auwerx J. NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab. 2015;22:31–53. - PMC - PubMed
1. Lee CF, Tian R. Mitochondrion as a Target for Heart Failure Therapy- Role of Protein Lysine Acetylation. Circ J. 2015;79:1863–1870. - PubMed
1. Wang W, Karamanlidis G, Tian R. Novel targets for mitochondrial medicine. Sci Transl Med. 2016;8:326rv3. - PMC - PubMed
1. Diguet Nicolas, Trammell Samuel AJ, Tannous Cynthia, Deloux Robin, Piquereau Jérôme, Mougenot Nathalie, Gouge Anne, Gressette Mélanie, Manoury Boris, Blanc Jocelyne, Breton Marie, Decaux Jean-François, Lavery Gareth, Baczkó István, Zoll Joffrey, Garnier Anne, Li Zhenlin, Brenner Charles, Mericskay Mathias. Circulation. 2017 CIRCULATIONAHA.116.026099. [In Press] - PMC - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

Grants and funding

R21 HL126209/HL/NHLBI NIH HHS/United States

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Ussher JR, Jaswal JS, Lopaschuk GD. Pyridine nucleotide regulation of cardiac intermediary metabolism. Circ Res. 2012;111:628–641. - PubMed

[2] Ussher JR, Jaswal JS, Lopaschuk GD. Pyridine nucleotide regulation of cardiac intermediary metabolism. Circ Res. 2012;111:628–641. - PubMed

[3] Canto C, Menzies KJ, Auwerx J. NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab. 2015;22:31–53. - PMC - PubMed

[4] Canto C, Menzies KJ, Auwerx J. NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab. 2015;22:31–53. - PMC - PubMed

[5] Lee CF, Tian R. Mitochondrion as a Target for Heart Failure Therapy- Role of Protein Lysine Acetylation. Circ J. 2015;79:1863–1870. - PubMed

[6] Lee CF, Tian R. Mitochondrion as a Target for Heart Failure Therapy- Role of Protein Lysine Acetylation. Circ J. 2015;79:1863–1870. - PubMed

[7] Wang W, Karamanlidis G, Tian R. Novel targets for mitochondrial medicine. Sci Transl Med. 2016;8:326rv3. - PMC - PubMed

[8] Wang W, Karamanlidis G, Tian R. Novel targets for mitochondrial medicine. Sci Transl Med. 2016;8:326rv3. - PMC - PubMed

[9] Diguet Nicolas, Trammell Samuel AJ, Tannous Cynthia, Deloux Robin, Piquereau Jérôme, Mougenot Nathalie, Gouge Anne, Gressette Mélanie, Manoury Boris, Blanc Jocelyne, Breton Marie, Decaux Jean-François, Lavery Gareth, Baczkó István, Zoll Joffrey, Garnier Anne, Li Zhenlin, Brenner Charles, Mericskay Mathias. Circulation. 2017 CIRCULATIONAHA.116.026099. [In Press] - PMC - PubMed

[10] Diguet Nicolas, Trammell Samuel AJ, Tannous Cynthia, Deloux Robin, Piquereau Jérôme, Mougenot Nathalie, Gouge Anne, Gressette Mélanie, Manoury Boris, Blanc Jocelyne, Breton Marie, Decaux Jean-François, Lavery Gareth, Baczkó István, Zoll Joffrey, Garnier Anne, Li Zhenlin, Brenner Charles, Mericskay Mathias. Circulation. 2017 CIRCULATIONAHA.116.026099. [In Press] - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Raising NAD in Heart Failure: Time to Translate?

Affiliations

Raising NAD in Heart Failure: Time to Translate?

Authors

Affiliations

Figures

Comment on

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Figures

Comment on

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical