Enterobacteria and host resistance to infection

Mamm Genome. 2018 Aug;29(7-8):558-576. doi: 10.1007/s00335-018-9749-4. Epub 2018 May 21.

Abstract

Enterobacteriaceae are a large family of Gram-negative, non-spore-forming bacteria. Although many species exist as part of the natural flora of animals including humans, some members are associated with both intestinal and extraintestinal diseases. In this review, we focus on members of this family that have important roles in human disease: Salmonella, Escherichia, Shigella, and Yersinia, providing a brief overview of the disease caused by these bacteria, highlighting the contribution of animal models to our understanding of their pathogenesis and of host genetic determinants involved in susceptibility or resistance to infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alleles
  • Animals
  • Disease Models, Animal
  • Disease Resistance* / genetics
  • Disease Resistance* / immunology
  • Disease Susceptibility*
  • Enterobacteriaceae / physiology*
  • Enterobacteriaceae Infections / genetics
  • Enterobacteriaceae Infections / immunology
  • Enterobacteriaceae Infections / metabolism
  • Enterobacteriaceae Infections / microbiology*
  • Host-Pathogen Interactions* / genetics
  • Host-Pathogen Interactions* / immunology
  • Humans
  • Quantitative Trait Loci