Objective: To summarize the research progress of microRNA (miRNA) in the osteoarthritis (OA) cartilage matrix degradation.
Methods: The domestic and foreign related literature about the miRNA in the OA cartilage matrix degradation was reviewed, summarized, and analyzed.
Results: OA is a common chronic joint disease characterized by cartilage degeneration, its etiology and pathogenesis are still not completely clear. miRNA, a kind of small single stranded non-coding RNA molecule, is closely correlated with inflammatory mediators and various cytokines during the cartilage matrix degradation, suggesting that miRNAs have important regulatory functions at the molecule and cellular levels.
Conclusions: miRNA can serve as potential biomarkers and will give new insight into diagnosis and therapeutic strategies in OA.
目的: 针对miRNA与骨关节炎（osteoarthritis，OA）软骨基质降解的研究进展进行综述。.
方法: 查阅国内外有关miRNA与OA软骨基质降解的文献，对其进行总结分析。.
结果: OA是一类常见的以软骨退行性病变为主要特征的慢性关节性疾病，其病因和发病机制尚不明确。miRNA是一种非蛋白编码小分子RNA，与OA软骨基质降解过程中的炎性介质及各种细胞因子密切相关，在细胞和分子水平调控软骨细胞基因表达中发挥重要作用。.
结论: miRNA可作为潜在分子靶标，为OA临床诊断和治疗提供新的方向。.
Keywords: Cartilage; Matrix degradation; MicroRNA; Osteoarthritis.