Fetal and Neonatal Ductus Arteriosus Is Regulated with ATP-Sensitive Potassium Channel

Kazuo Momma; Mika Monma; Katsuaki Toyoshima; Emiko Hayama; Toshio Nakanishi

doi:10.1007/978-4-431-54628-3_37

Fetal and Neonatal Ductus Arteriosus Is Regulated with ATP-Sensitive Potassium Channel

Review

In: Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 37.

2016 Jun 25.

Authors

Kazuo Momma¹, Mika Monma², Katsuaki Toyoshima³, Emiko Hayama¹, Toshio Nakanishi¹

Book Editors

Toshio Nakanishi¹, Roger R. Markwald², H.Scott Baldwin³, Bradley B. Keller⁴, Deepak Srivastava⁵, Hiroyuki Yamagishi⁶

Affiliations

¹ Department of Pediatric Cardiology, Tokyo Women’s Medical University, Kawadacho 8-1, Shinjyuku-ku, Tokyo, 162-8666, Japan
² Department of Obstetrics and Gynecology, Shounan-Kamakura General Hospital, Okamoto 1370-1, Kamakura, 247-8533, Japan
³ Department of Neonatology, Kanagawa Children’s Medical Center, Mutukawa 2-138-4 Minamiku, Yokohama, 232-8555, Japan

Book Affiliations

¹ Department of Pediatric Cardiology, Tokyo Women's Medical University, Tokyo, Japan
² Cardiovascular Developmental Biology Center, Medical University of South Carolina Clemson University, Charleston, South Carolina, USA
³ Department of Pediatrics (Cardiology), Vanderbilt University, Nashville, Tennessee, USA
⁴ Pediatrics, Pharmacology and Toxicology, and Bioengineering, University of Louisville, Louisville, Kentucky, USA
⁵ Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
⁶ Pediatrics, Division of Pediatric Cardiology, Keio University School of Medicine, Tokyo, Japan

Excerpt

The fetal patency and neonatal closure of the ductus arteriosus (DA) are regulated with oxygen and prostaglandins. The proposed oxygen sensors of fetal and neonatal DA include P450-endothelin and the Kv channel [1]. We hypothesized that the ATP-sensitive potassium channel (K_ATP channel) is another oxygen sensor [2].

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