Hydroxylamine Derivatives as Nitrogen-Radical Precursors in Visible-Light Photochemistry

Jacob Davies; Sara P Morcillo; James J Douglas; Daniele Leonori

doi:10.1002/chem.201801655

Hydroxylamine Derivatives as Nitrogen-Radical Precursors in Visible-Light Photochemistry

Chemistry. 2018 Aug 22;24(47):12154-12163. doi: 10.1002/chem.201801655. Epub 2018 Jul 6.

Authors

Jacob Davies¹, Sara P Morcillo¹, James J Douglas², Daniele Leonori¹

Affiliations

¹ School of Chemistry, University of Manchester, Oxford Road, M13 9PL, Manchester, UK.
² Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield, SK10 2NA, UK.

PMID: 29787627
DOI: 10.1002/chem.201801655

Abstract

In recent years, hydroxylamines derivatives have been exploited as nitrogen-radical precursors in visible-light photochemistry. Their ability to serve as electrophores in redox chemistry has propelled the development of many novel transformations. Fundamental mechanistic aspects as well as the importance in the preparation of nitrogen-containing molecules will be highlighted.

Keywords: hydroxylamine derivatives; nitrogen radicals; photoredox catalysis; single-electron transfer; visible light.