Evaluation of aromatherapy with essential oils of Rosa damascena for the management of premenstrual syndrome

Int J Gynaecol Obstet. 2018 Aug;142(2):156-161. doi: 10.1002/ijgo.12534. Epub 2018 Jun 8.


Objective: To investigate the efficacy of aromatherapy with essential oils of Rosa damascena for the management of premenstrual syndrome (PMS).

Methods: The present triple-blind randomized clinical trial was conducted between March 5, 2016, and February 20, 2017, among female students attending Shiraz University of Medical Sciences, Shiraz, Iran, who experienced PMS, had a menstrual cycle of 24-35 days, were not using vitamin supplements or hormonal drugs, and did not have any underlying diseases. Block randomization was used to assign participants to an intervention group receiving aromatherapy with R. damascena at a 4% concentration or a control group who received aromatherapy with 100% sweet almond oil. Aromatherapy was performed for 5 minutes, twice daily, for a total of 5 days during the luteal phase. The premenstrual symptoms screening tool questionnaire was completed at baseline and after 1 and 2 months of treatment. Per-protocol analyses were performed with patients and investigators masked to group assignments.

Results: There were 66 participants enrolled and 64 completed the study (33 in the intervention group and 31 in the control group). At 2 months, aromatherapy with R. damascena was associated with improved psychological (P<0.001), physical (P<0.001), social (P=0.002), and total (P<0.001) PMS symptoms compared with baseline. By contrast, no improvements were recorded in the control group.

Conclusion: Aromatherapy with R. damascena improved multiple symptoms of PMS.

Iranian registry of clinical trials: IRCT2016031113940N3.

Keywords: Rosa damascena; Aromatherapy; Essential oil; Luteal phase; Premenstrual syndrome; Student.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aromatherapy / methods*
  • Female
  • Humans
  • Iran
  • Luteal Phase
  • Oils, Volatile / therapeutic use*
  • Plant Oils / therapeutic use
  • Premenstrual Syndrome / therapy*
  • Research Design
  • Rosa*
  • Treatment Outcome
  • Young Adult


  • Oils, Volatile
  • Plant Oils
  • almond oil