Progress toward development of a proteostasis drug for myocilin-associated glaucoma

Future Med Chem. 2018 Jun 1;10(12):1391-1393. doi: 10.4155/fmc-2018-0073. Epub 2018 May 23.
No abstract available

Keywords: Grp94; aggregation; glaucoma; inhibitor; meshwork; myocilin; proteostasis; trabecular.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Cytoskeletal Proteins / analysis
  • Cytoskeletal Proteins / genetics
  • Cytoskeletal Proteins / metabolism*
  • Drug Discovery*
  • Eye Proteins / analysis
  • Eye Proteins / genetics
  • Eye Proteins / metabolism*
  • Glaucoma / drug therapy*
  • Glaucoma / genetics
  • Glaucoma / metabolism*
  • Glycoproteins / analysis
  • Glycoproteins / genetics
  • Glycoproteins / metabolism*
  • Humans
  • Membrane Glycoproteins / antagonists & inhibitors
  • Membrane Glycoproteins / metabolism
  • Molecular Targeted Therapy
  • Mutation
  • Protein Aggregates / drug effects
  • Proteostasis / drug effects*

Substances

  • Cytoskeletal Proteins
  • Eye Proteins
  • Glycoproteins
  • Membrane Glycoproteins
  • Protein Aggregates
  • endoplasmin
  • trabecular meshwork-induced glucocorticoid response protein