Advances in the Tyrosinase Inhibitors From Plant Source

Curr Med Chem. 2019;26(18):3279-3299. doi: 10.2174/0929867325666180522091311.


Tyrosinase is a multifunctional copper-containing oxidase which catalyses the oxidation of tyrosine to produce melanin. The alteration in melanin biosynthesis occurs in many diseases. The pigment has a protecting role against skin photo-carcinogenesis, but anomalous melanin pigmentation is an aesthetic problem in human beings. Moreover, the formation of neuromelanin in human brain could contribute to the neurodegeneration associated with Parkinson's disease. Finally, tyrosinase is also responsible for undesired browning in fruits and vegetables. These topics encouraged the search for new inhibitors of this enzyme for pharmaceutical, cosmetic and foods industries. This review is to report recent trends in the discovery of tyrosinase inhibitors from plant sources, to provide a rationale for the continued study of natural tyrosinase inhibitors, and to recognise the potential therapeutic rewards associated with the identification of these agents.

Keywords: Tyrosinase; extract; melanogenesis; natural compounds; plant source; polyphenols..

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Products* / chemistry
  • Biological Products* / pharmacology
  • Biological Products* / therapeutic use
  • Drug Evaluation, Preclinical
  • Enzyme Inhibitors* / chemistry
  • Enzyme Inhibitors* / pharmacology
  • Enzyme Inhibitors* / therapeutic use
  • Humans
  • Melanins / chemistry
  • Melanins / metabolism
  • Monophenol Monooxygenase / antagonists & inhibitors*
  • Parkinson Disease / drug therapy*
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plants / chemistry*


  • Biological Products
  • Enzyme Inhibitors
  • Melanins
  • Plant Extracts
  • Monophenol Monooxygenase