Dynamic transcriptomic m 6 A decoration: writers, erasers, readers and functions in RNA metabolism

Cell Res. 2018 Jun;28(6):616-624. doi: 10.1038/s41422-018-0040-8. Epub 2018 May 22.

Abstract

N6-methyladenosine (m6A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m6A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m6A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / genetics
  • Adenosine / metabolism
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO / metabolism
  • Animals
  • Humans
  • Methyltransferases / metabolism
  • RNA / genetics
  • RNA / metabolism*
  • RNA Isoforms / genetics
  • RNA Isoforms / metabolism
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / metabolism
  • Transcriptome*

Substances

  • RNA Isoforms
  • RNA, Messenger
  • RNA-Binding Proteins
  • N(6)-methyladenosine
  • RNA
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO
  • Methyltransferases
  • Adenosine