Three New Heptelidic Acid Derivatives from the Culture of Mushroom Lentinellus ursinus

Li Liu; Jun-Jie Han; Tian-Shun Xu; Rui-Xing Liu; Li Bao; Hong-Wei Liu

doi:10.1007/s13659-018-0168-8

Three New Heptelidic Acid Derivatives from the Culture of Mushroom Lentinellus ursinus

Nat Prod Bioprospect. 2018 Oct;8(5):355-360. doi: 10.1007/s13659-018-0168-8. Epub 2018 May 22.

Authors

Li Liu^{1

2}, Jun-Jie Han^{1

2}, Tian-Shun Xu³, Rui-Xing Liu^{1

2}, Li Bao¹, Hong-Wei Liu^{4

5}

Affiliations

¹ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
² Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
³ College of Life Sciences, Hebei University, Baoding, 071002, China.
⁴ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China. liuhw@im.ac.cn.
⁵ Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China. liuhw@im.ac.cn.

Abstract

Three new heptelidic acid derivatives (1-3) including two new dimeric esters and two known heptelidic acid analogues (4 and 5) were isolated from the solid culture of mushroom Lentinellus ursinus. The structures of new compounds were confirmed by the analysis of NMR and HRESIMS spectroscopic data. The biosynthetic origin of compounds 1-5 was postulated. Compounds 1-5 exhibited no antibacterial activity against Staphylococcus aureus and Escherichia coli at the dose of 100 μM.

Keywords: Biosynthetic pathway; Heptelidic acid derivatives; Lentinellus ursinus.

Abstract

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