Past and Present: A Review of Antenatal Corticosteroids and Recommendations for Late Preterm Birth Steroids

Am J Perinatol. 2018 Nov;35(13):1241-1250. doi: 10.1055/s-0038-1653944. Epub 2018 May 23.


Since 1972, the beneficial neonatal effects of antenatal corticosteroids (ACSs) have been repeatedly demonstrated in pregnancies at risk of preterm birth before 34 weeks' gestation. While ACS utilization before 34 weeks has been high since the 1990s, knowledge gaps regarding the risks and benefits of ACS continue to exist. Recent evidence has been published regarding the benefit of ACS in the late preterm period. This review addresses the evidence and knowledge gaps for ACS use before and after 34 weeks' gestation. We also provide recommendations for ACS use in the late preterm period.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / pharmacology*
  • Female
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Premature Birth / prevention & control
  • Prenatal Care* / methods
  • Prenatal Care* / trends
  • Prenatal Exposure Delayed Effects* / chemically induced
  • Prenatal Exposure Delayed Effects* / diagnosis
  • Risk Assessment


  • Adrenal Cortex Hormones