The effect of the modes of delivery on the maternal and neonatal dynamic thiol-disulfide homeostasis

J Matern Fetal Neonatal Med. 2019 Dec;32(23):3993-3997. doi: 10.1080/14767058.2018.1481028. Epub 2018 Jun 19.

Abstract

Background: Thiols are organic compounds containing sulfhydryl groups which exert antioxidant effects via dynamic thiol-disulfide homeostasis. The shift towards disulfide indicates the presence of oxidative environment. The thiol-disulfide homeostasis has not been studied in different mode of delivery before. Aims: To investigate the effects of mode of parturition on the thiol-disulfide homeostasis in mothers and term infants. Study design: The participants were grouped according to the mode of their delivery: group vaginal delivery (VD, n = 40) and group cesarean section (C/S, n = 40). Three serum samples were collected: from mothers at the beginning of labor, from the cord blood (CB), and from the infants at the 24th hour after birth. The dynamic thiol-disulfide homeostasis in both groups were compared. Results: The levels of native-thiol and total-thiol in CB were significantly higher in VD group than those with C/S group. The levels of disulfide were higher in infants born by C/S compared with those born by VD. The disulfide-to-native thiol ratio, disulfide-to-total thiol ratio, and native thiol-to-total thiol ratio were similar between two groups. Conclusion: Our results showed that the dynamic thiol-disulfide homeostasis of the neonate was greatly influenced by the way of delivery and supported that vaginally delivered infants have less oxidative stress.

Keywords: Mode of delivery; newborn; thiol–disulfide homeostasis.

MeSH terms

  • Adult
  • Delivery, Obstetric / adverse effects
  • Delivery, Obstetric / methods*
  • Disulfides / blood*
  • Female
  • Fetal Blood / chemistry*
  • Homeostasis
  • Humans
  • Infant, Newborn
  • Male
  • Mothers
  • Oxidative Stress / physiology
  • Parturition / blood*
  • Pregnancy
  • Prospective Studies
  • Sulfhydryl Compounds / blood*
  • Young Adult

Substances

  • Disulfides
  • Sulfhydryl Compounds