Isochromanes from Aspergillus fumigatus, an endophytic fungus from Cordyceps sinensis

Nat Prod Res. 2019 Jul;33(13):1870-1875. doi: 10.1080/14786419.2018.1478824. Epub 2018 May 24.

Abstract

Four previously undescribed isochromanes were isolated from the fermentation broth of an endophytic fungus Aspergillus fumigatus, which was obtained from the fruiting body of Cordyceps sinensis. Their structures were elucidated through extensive spectroscopic analyses. One racemic isochromane was further purified by chiral HPLC to yield a pair of enantiomers and their absolute configurations were determined by quantum chemical ECD calculations. These isolated compounds were evaluated for cytotoxicity against two cell lines (MV4-11 and MDA-ME-231) and the result showed that compounds 1a and 2 exhibited moderate growth inhibition against MV4-11 cell line.

Keywords: azaphilone; cytotoxicity; isochromane.

MeSH terms

  • Aspergillus fumigatus / chemistry*
  • Cell Line
  • Cell Proliferation / drug effects
  • Chromans / chemistry
  • Chromans / isolation & purification*
  • Chromans / pharmacology
  • Cordyceps*
  • Cytotoxins / isolation & purification
  • Growth Inhibitors / isolation & purification
  • Humans
  • Molecular Structure
  • Spectrum Analysis
  • Stereoisomerism

Substances

  • Chromans
  • Cytotoxins
  • Growth Inhibitors