A double-blind crossover comparison of lidamidine, loperamide and placebo for the control of chronic diarrhoea

Aliment Pharmacol Ther. 1988 Aug;2(4):347-51. doi: 10.1111/j.1365-2036.1988.tb00707.x.


Fourteen patients with chronic diarrhoea, but no evidence of active organic disease, completed a double-blind crossover comparison of the anti-diarrhoeal effects of loperamide, placebo and the clonidine analogue, lidamidine. Failure of diarrhoea control led to early withdrawals from seven placebo- and six lidamidine-treatment periods, but there was only one early withdrawal during treatment with loperamide. Loperamide was found to be superior to lidamidine or placebo for the control of stool consistency in patients with chronic diarrhoea.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Antidiarrheals / therapeutic use*
  • Chronic Disease
  • Diarrhea / drug therapy*
  • Double-Blind Method
  • Female
  • Humans
  • Loperamide / therapeutic use*
  • Male
  • Middle Aged
  • Phenylurea Compounds / therapeutic use*


  • Antidiarrheals
  • Phenylurea Compounds
  • Loperamide
  • lidamidine